The intranasal route of estrogen administration provides a new, unique pharmacokinetic profile: “pulsating”. It is characterized by the maximum plasma concentration of estradiol which is attained rapidly, which then also quickly returns to its original level. The intranasal route of […]
Antiandrogens
Antiandrogens are necessary in M / F transgender substitution therapy, especially in the preoperative period, as they allow to reduce the dose of estrogen. In Europe and Russia, the drug of choice is cy-proterone acetate (androcur, Schering AG), which inhibits […]
Progestogens
Progestogen preparations themselves do not produce a feminizing effect, but they are often included in the combination therapy of patients with transsexualism, mainly as part of estrogen-gestogenic drugs. In the literature, there are quite contradictory data on the effect of […]
Finasteride and Agonists
Finasteride is a drug for treating benign prostatic hyperplasia (adenoma). Finasteride is a synthetic 4-azasteroid compound. It is a competitive inhibitor of 5-alpha-reductase type II – an intracellular enzyme that turns testosterone into a more active androgen – dihydrotestosterone. In […]
Effects of hormone therapy in patients with M / F-transsexualism
The positive effects of estrogen therapy in patients with M / W-transsexualism include: Reduction of hair distribution for the male type. Pubic, armpit, facial hair become thinner and less pigmented. However, the most resistant to hormone therapy, even in combination […]
Modes of hormonal therapy for M / G-transsexualism
We recommend starting HRT in M / F transgender at least 6 months. before the planned surgery and stop for 3-4 weeks. before the planned operation due to the increased risk of thromboembolism as a result of prolonged immobilization. After […]
Monitoring of patients with M / W transsexualism
The indications for monitoring patients with M / F-transsexualism, as well as the parameters for assessing body functions, were developed by us taking into account the analysis of recent literature data, “Standards for providing medical care for gender identity disorders” […]
Modern approaches to androgen therapy
The modern stage of development of therapy with androgens began with the development in the 1930s in the Netherlands and Germany by divisions of the company Organon of the technology of industrial synthesis of testosterone. In the work “On the […]
Androgen therapy for F / M transsexualism
Difficulties with hormone therapy (androgen therapy) in F / M transsexualism, as a rule, does not arise. Patients themselves come to the endocrinologist for the purpose of treatment, because they understand that they have no source of male sex hormones […]
Effects of androgen therapy in F / M transsexualism
We observed 450 patients with F / M-transsexualism. A complete hormonal examination was performed in 50 patients. All patients received androgen therapy for a period of 1 month. up to 4 years and were divided into two groups: Group 1 […]